Bach2 regulates AID-mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells
نویسندگان
چکیده
منابع مشابه
Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells.
The activation induced cytosine deaminase (AID) mediates diversification of B cell immunoglobulin genes by the three distinct yet related processes of somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion (GCV). SHM occurs in germinal center B cells, and the transcription factor Bcl6 is a key regulator of the germinal center B cell gene expression program, including...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2017
ISSN: 0014-2980
DOI: 10.1002/eji.201646895